Azelaic Acid

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Categories: Dicarboxylic Acid

Type: Dicarboxylic Acid
Name: Azelaic Acid
RDA: None Listed, (varies from person to person), 10% concentration in solution is generally sufficient, 15-20% qualifies as prescription strength
Importance- to Body:
Anti-inflammatory, Antibacterial,Treats Acne and Rosacea, Melasma
Naturally occuring Exfoliant, Anti-inflammatory, Anti-bacterial. Kills acne bacteria. Reduces inflammation clears bumps caused by rosacea, and other visible skin disorders (brown patches, post- acne blemishes), dull skin tone, signs of sensitivities
Distribution- in Body:
Skin (Surface, Uppermost layers)
Excess Effects:
Burning, Stinging, Dry Skin, Redness, Itching, Irritation, Tightness;

Excess Effects:
Dizziness, Headaches, Nausea, Contact Dermatitis, Changing of skin color
Deficiency Effects:

Food Sources:
Whole Grains such as Barley, Wheat, and Rye
Environmental/Geographic Sources:
Natural biproduct of Malassezia furfur (a yeast that lives symbiotically on human skin)
Supplemental information:
Can be found in: Topical Gels, Creams, Foams

Synonyms:
Finacea, Azelac, Dermaz 99, Azaclear
Azelaic Acid (Wikipedia)
Azelaic acid
Skeletal formula of azelaic acid
Ball-and-stick model of the azelaic acid molecule
Names
IUPAC name
nonanedioic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.004.246
KEGG
UNII
Properties
C9H16O4
Molar mass 188.22 g/mol
Appearance white solid
Density 1.443 g/mL
Melting point 109 to 111 °C (228 to 232 °F; 382 to 384 K)
Boiling point 286 °C (547 °F; 559 K) at 100 mmHg
2.14 g/L
Acidity (pKa) 4.550, 5.498
Pharmacology
D10AX03 (WHO)
Topical
Pharmacokinetics:
Very low
12 h
Legal status
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Azelaic acid is an organic compound with the formula HOOC(CH2)7COOH. This saturated dicarboxylic acid exists as a white powder. It is found in wheat, rye, and barley. It is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners.

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