Histidine

Type: Essential Amino Acid
Name: Histidine (His), Chemical Formula C6H9N302
RDA: Doses that are therapeutic of histidine range from .5 to 20 grams per day, although 30 grams of histidine in supplemental form has shown no adverse side effects.
Importance- to body:
Develops and maintains healthy tissues and is essential in maintaining the myelin sheath that coat nervous cells and send messages from the brain to other organs in the body. Histidine is also being further researched on its effects of preventing radiation damage (histidine can detox the body naturally and produce white and red blood cells).
Distribution- in body: Brain.
Excess effects:
Stress, Anxiety. Those with schizophrenia are found having higher levels of histidine.
Deficiency effects:
Eczema, stress, anxiety, disorientation, fatigue.
Food Sources:
Fish, Meats, Eggs, Dairy products.
Environmental/Geographic Sources:
Supplemental information: May be able to treat mental disorders and sexual dysfunction. Available in both supplemental and powder form, Histidine is recommended for those with arthritis or those who are chronically ill. Histidinemia is a very rare disorder where there are high levels of histidine in urine and blood because of the insufficient amount of the enzyme (histidase) that’s needed to break down histidine. Histidine is used as a medicine!

Works Cited:
1. C.D.N., Erica Wickham M.S. R.D. “What Foods Contain Histidine?” LIVESTRONG.COM, Leaf Group, 3 Oct. 2017, www.livestrong.com/article/517676-what-foods-contain-histidine/.

Histidine (Wikipedia)

L-Histidine

Names
IUPAC name Histidine
Other names 2-Amino-3-(1H-imidazol-4-yl)propanoic acid
Identifiers
CAS Number	71-00-1 Y
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:57595 Y
ChEMBL	ChEMBL17962 Y
ChemSpider	6038 Y
DrugBank	DB00117 Y
ECHA InfoCard	100.000.678
IUPHAR/BPS	3310
KEGG	D00032 Y
PubChem CID	773
UNII	4QD397987E Y
InChI InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 Y Key: HNDVDQJCIGZPNO-YFKPBYRVSA-N Y InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 Key: HNDVDQJCIGZPNO-YFKPBYRVSA-N
SMILES O=C([C@H](CC1=CNC=N1)N)O O=C(O)[C@@H](N)Cc1c[nH]cn1
Properties
Chemical formula	C6H9N3O2
Molar mass	155.16 g·mol−1
Solubility in water	4.19g/100g @ 25 °C
Hazards
Safety data sheet	See: data page
NFPA 704	1 1 0
Supplementary data page
Structure and properties	Refractive index (n), Dielectric constant (εr), etc.
Thermodynamic data	Phase behaviour solid–liquid–gas
Spectral data	UV, IR, NMR, MS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is Y ?)
Infobox references

Histidine (symbol His or H) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated –NH₃⁺ form under biological conditions), a carboxylic acid group (which is in the deprotonated –COO⁻ form under biological conditions), and an imidazole side chain (which is partially protonated), classifying it as a positively charged amino acid at physiological pH. Initially thought essential only for infants, longer-term studies have shown it is essential for adults also. It is encoded by the codons CAU and CAC.

Histidine was first isolated by German physician Albrecht Kossel and Sven Hedin in 1896. It is also a precursor to histamine, a vital inflammatory agent in immune responses. The acyl radical is histidyl.